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4-AcO-DET (4-Acetoxy-N,N-diethyltryptamine, ethacetin) is a lesser-known novel psychedelic substance of the tryptamine class. It is chemically related to psilocin and part of a series of substituted tryptamines that includes 4-AcO-MET and 4-AcO-DMT.

4-AcO-DET, or 4-Acetoxy-N.N-diethyltryptamine, is a synthetic indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-AcO-DET is substituted at R4 of its indole heterocycle with an acetoxy (AcO) functional group CH3COO−. It also contains two ethyl chains bound to the terminal amine RN of its tryptamine backbone (DET).

4-AcO-DET is the N-substituted diethyl homolog of 4-HO-DMT (psilocin). 4-AcO-DET is the acetate ester analog of DET and the N-substituted diethyl analog of 4-AcO-DMT. It is a higher homolog of 4-AcO-DMT and 4-AcO-MET.

4-substituted acetylated tryptamines such as 4-AcO-DET, 4-AcO-MET, and 4-AcO-DMT are hypothesized to principally act as a prodrug for their respective hydrolyzed counterparts (e.g. 4-HO-DMT, 4-HO-MET and 4-HO-DET).

Like with most psychedelic tryptamines, 4-AcO-DET is thought to act principally as a 5-HT2A partial agonist. The psychedelic effects are believed to come from 4-AcO-DET's binding efficacy at the 5-HT2A receptors.

In terms of its effects on the physical energy levels of the user, 4-AcO-DET is typically relaxing, stoning and mildly sedating, although it can also sometimes be very stimulating and give users a "wired" feeling. This sense of sedation is often accompanied by uncontrollable yawning.

The "body high" of 4-AcO-DET can be described as a pleasurable, warm, soft and all-encompassing tingling sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.

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How to Buy 4-AcO-DET

Discover and purchase 4-AcO-DET along with a variety of other research chemicals at Shulgin's Lab. We ensure that all our chemicals undergo rigorous third-party lab testing for quality and safety. If you're interested in viewing the HNMR results for 4-AcO-DET or any other chemical, feel free to reach out to us via email at

Engaging in Responsible Research with 4-AcO-DET

It is essential to engage in responsible research practices. We encourage you to thoroughly read and educate yourself before conducting any research with chemicals. The Psychonaut Wiki offers valuable resources and insights on 4-AcO-DET , as does The Third Wave. Always ensure you have a solid understanding of a chemical before proceeding with any research.

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Please note that 4-AcO-DET and all other products are intended strictly for research purposes and are not suitable for human consumption.

Store 4-AcO-DET in a cool, dry place away from sunlight.

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4-AcO-DET stock last updated at: March 2026