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LysergamidesSynthetic CathinonesAmphetaminesArylcyclohexylaminesPhenethylaminesTryptaminesPhenidatesBenzofuransSynthetic CannabinoidsBenzodiazepinesOtherNootropics

4-HO-DET Tryptamines

gr(s)

Status: AVAILABLE [25/06/2026]

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SMART PRICING:
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1 to 2 EUR 94.00 /gr Save 0%
3 to 4 EUR 84.60 /gr Save 10%
5 to 9 EUR 75.20 /gr Save 20%
10 to 24 EUR 61.10 /gr Save 35%
25 + EUR 51.70 /gr Save 45%

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4-HO-DET is a psychedelic substance of the tryptamine class. The drug’s effects are almost identical to those of psilocybin mushrooms.

4-Hydroxy-N,N-diethyltryptamine (also known as 4-HO-DET, CZ-74, and Ethocin) is a lesser-known synthetic psychedelic of the tryptamine chemical class that produces psilocin-like psychedelic effects when adminstered. 4-HO-DET is a close structural and functional analog of psilocin (4-HO-DMT), the principal psychoactive component in magic mushrooms. It is notable for sharing many of its core features while retaining subtle variations in its duration, visual, cognitive and bodily effects.

This compound was first discovered in the late 1950s by Albert Hofmann and Franz Troxler in their investigation of various psychedelic compounds that were structurally and chemically related to the principle active components he isolated from magic mushrooms, psilocybin (4-PO-DMT) and psilocin (4-HO-DMT).

AN USER EXPERIENCE ABOUT 4-HO-DET:
" ... All in all, I loved this tryptamine. It gives amazing vibes and clear, interesting thoughts. Do your research beforehand though and make sure you’re ready for the trip you’re about to experience. Don’t go in blindly. I can say though that I will definitely be trying this again!! The trip lasted about 4 1/2 hours total. Hope this experience report helps. Happy tripping and keep it safe and fun!!"
How to Buy 4-HO-DET

Discover and purchase 4-HO-DET along with a variety of other research chemicals at Shulgin's Lab. We ensure that all our chemicals undergo rigorous third-party lab testing for quality and safety. If you're interested in viewing the HNMR results for 4-HO-DET or any other chemical, feel free to reach out to us via email at

Engaging in Responsible Research with 4-HO-DET

It is essential to engage in responsible research practices. We encourage you to thoroughly read and educate yourself before conducting any research with chemicals. The Psychonaut Wiki offers valuable resources and insights on 4-HO-DET , as does The Third Wave. Always ensure you have a solid understanding of a chemical before proceeding with any research.

Please note that 4-HO-DET and all other products are intended strictly for research purposes and are not suitable for human consumption.

Store 4-HO-DET in a cool, dry place away from sunlight.

4-HO-DET stock last updated at: June 2026